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Innovating Next-Generation Therapeutics with Advanced Polymers

Pleryon is a world pioneer in developing polymer-based therapeutics. Our mission is to develop novel treatments for multiple unmet medical needs by utilizing our proprietary technology that controls the 2D sequence and 3D structure of extra-large polymeric molecules. By targeting diseases through physical, mechanical and biological means, we are pioneering a new way to treat complex and multifactorial diseases.

Product Pipelines

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P001X

Synthetic lubricating polymer for the treatment of osteoarthritis

Knee Osteoarthritis (OA) represents a significant yet underserved market, with nearly 600 million people affected globally. Current treatment options, such as steroid and HA injections, are either harmful to articular cartilage or ineffective.

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P001X is an intra-articular injection designed for osteoarthritis. It is a pioneering synthetic di-block copolymer that provide boundary lubrication for the knee joints.

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M001

Low-density crosslinked HA for the treatment of dry eye disease

Dry Eye Disease (DED) is another significant yet underserved market, with over 300 million people affected globally. Currently, there is no cure for the disease, and 60-70% of patients are dissatisfied with existing treatments due to their lack of efficacy.

 

M001 is a topical ultrasoft hydrogel for dry eye disease that sets a new benchmark for ocular surface retention and anti-inflammatory activity.

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M007

Microstructure-Controlled Hydrogel for Regenerative Aesthetics

Aesthetic injections are becoming a mainstream procedure for consumers wishing to enhance their appearance, with over 10 million injections performed annually. However, many consumers are dissatisfied with their results.

 

M007 is a state-of-the-art regenerative aesthetic injectable.

Publications

  • A bioinspired synthetic soft hydrogel for the treatment of dry eye, Y Yu, Derek Wai Yee Chow, C Lau, G Zhou, W Back, J Xu, S Carim, Y Chau, Bioengineering & Translational Medicine. 2021, e10227.

  • Boundary mode lubrication of articular cartilage with a biomimetic diblock copolymer, Z Sun, E Feeney, Y Guan, S Cook, D Gordon, L Bonassar, D Putnam, Proceedings of the National Academy of Sciences. 2019, 116(25), 12437-12441.

  • The influence of block length on articular cartilage lubrication with a diblock bottlebrush copolyme, Z Sun, L Bonassar, D Putnam, ACS Applied Materials & Interfaces. 2019, 12(1), 330-337.

  • Formulation of in situ chemically-crosslinked hydrogel depots for protein release: from the blob model perspective, Y Yu and Y Chau, Biomacromolecules. 2015, 16(1), 56-65. doi: 10.1021/bm501063n.

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